Graphical AbstractBottom-up metabolic systems biology is of particular relevance to biochemists. The jargon of bottom-up metabolic systems biology however represents a major obstacle that needs to be overcome by a prospective practitioner in this emerging field. Herein, we diminish this early hurdle by providing a lexicon of the most important terms.

Living organisms are exposed to numerous influencing factors. This holds also true for their infrastructures that are processing and transducing information like endocrine networks or nerval channels. Therefore, the ability to compensate for noise is crucial for survival. An efficient mechanism to neutralise disturbances is instantiated in form of parallel complementary communication channels exerting antagonistic effects at their common receivers. Different signal processing types share the ability to suppress noise, to widen the system’s regulation capacity, and to provide for variable (...) gains while leaving the transferred signal to a large extent unchanged. (shrink)

Inflammatory immune cells, when activated, display much the same metabolic profile as a glycolytic tumor cell. This involves a shift in metabolism away from oxidative phosphorylation towards aerobic glycolysis, a phenomenon known as the Warburg effect. The result of this change in macrophages is to rapidly provide ATP and metabolic intermediates for the biosynthesis of immune and inflammatory proteins. In addition, a rise in certain tricarboxylic acid cycle intermediates occurs notably in citrate for lipid biosynthesis, and succinate, which activates the (...) transcription factor Hypoxia‐inducible factor. In this review we take a look at the emerging evidence for a role for the Warburg effect in the immune and inflammatory responses. The reprogramming of metabolic pathways in macrophages, dendritic cells, and T cells could have relevance in the pathogenesis of inflammatory and metabolic diseases and might provide novel therapeutic strategies. (shrink)

We define a generalized notion of rank for stable theories without dense forking chains, and use it to derive that every type is domination-equivalent to a finite product of regular types. We apply this to show that in a small theory admitting finite coding, no realisation of a nonforking extension of some strong type can be algebraic over some realisation of a forking extension.

The precarious rights of senior citizens, especially those who are highly educated and who are expected to counsel and guide the younger generations, has stimulated the creation internationally of advocacy associations and opinion leader groups. The strength of these groups, however, varies from country to country. In some countries, they are supported and are the focus of intense interest; in others, they are practically ignored. For this is reason we believe that the creation of a network of all these associations (...) is essential. The proposed network would act as a support for the already-existing policies of the United Nations’ High Commission for Human Rights, of independent experts, and of the Global Alliance for the Rights of Older People. All three have long ago recommended the creation of a recognized instrument for uniting presently scattered efforts. The proposed network, therefore, will seek to promote the international exchange of relevant expertise, and it will reinforce the commitments and actions that single countries are currently taking to meet these objectives. For example, informative public events can be organised to promote particular support initiatives and to provide an opportunity for new members of the network to be presented. The network will promote health for senior citizens, disease prevention, senior mobility, safe free time for seniors, alimentary education, protection against new risks and dangers, as well as equity in the services necessary for seniors to adopt new information and communication technologies. In the case of retired academic members, the network will promote equality with respect to continuing use of digital technologies (particularly email), continuing access to research libraries, and the guaranteed ability for seniors to fund their own research programs and to deliver free seminars. (shrink)

The goal of the following study is to investigate whether first-year students in STEM fields that have a low proportion of females (STEM-L) show vocational interests that fit their vocational aspirations. To place our investigation into a broader context, we compared students in STEM-L with students of STEM subjects with a medium proportion of women (STEM-M) as well as with other subjects with a medium or a high proportion of females. We analyzed their vocational interests, vocational aspirations and their interest (...) congruence. In both the comparison regarding interest profiles and the comparison of vocational aspirations, we focused on the things-orientation and people-orientation, all while taking respective gender differences into account. Following the suggestion from previous studies, in a further step we differentiated between subjects within STEM-L. Using data from the German National Educational Panel Study (NEPS), we analyzed the interest congruence of 5530 male and 7406 female students in STEM majors (with a low or medium proportion of women) and non-STEM majors (with a medium or high proportion of women). Students from different subjects showed different magnitudes regarding their things- and people-orientation. STEM-L students had a high things-orientation and a low people-orientation regarding both their interests and aspired occupations. Students of STEM-L and STEM-M showed a lower interest congruence than students from other subjects. With the exception of education, gender differences regarding the people- and things-orientation also existed within most of the subjects. Gender differences partly remain when distinguishing between the different subjects within STEM-L. And so, the result that not all STEM-L subjects are “created equal” is discussed in the context of their theoretical and methodological aspects. (shrink)

"Pensar Europa en sus fronteras", como ya en 1992 proponían un grupo de filósofos de la Universidad de Estrasburgo -Denis Guénoun, Philippe Lacoue-Labarthe, Jean-Luc Nancy, Daniel Payot-, significa considerar qué es eso de la "geofilosofía de Europa" como una cuestión imprescindible que conlleva toda reflexión veraz en torno a la idea de Europa. El debate al que invitaron a una serie diversa de colegas y amigos, procedentes de diferentes naciones, planteaba la posibilidad misma de una identificación de Europa, así como (...) la profundidad, esto es, la misma violencia que esta posibilidad conlleva, como los hechos de la más reciente y rabiosa actualidad han confirmado una y otra vez desde aquellas fechas. La propuesta era todo menos fútil. En efecto, como es bien sabido y ellos mismos expresaron unos meses después, en julio de 1993, lo bien cierto es que ha habido terribles furores desencadenados y atroces desgarramientos tanto intra como extraeuropeos, que como mínimo nos urgen a pensar si el proyecto de lo que merece llamarse un 'mundo' puede o no puede confundirse con la exclusiva exportación de aquello que Europa habría inventado, producido e identificado. El futuro parece atenazado por dos figuras mórbidas, dos pesadillas simétricas, la mítica de un planeta homogéneo, como una gigantesca Europa que se extendiera por doquier, y la de una Europa recluida, encerrada en sus imprecisas e inciertas fronteras, una especie de barricadas o trincheras aislantes para que ella devorase en solitario el espejismo de su supuesto bienestar. Esta deplorable alternativa concita parte de nuestras responsabilidades, pues los escenarios del futuro se alimentan necesariamente de formas y de proposiciones de pensamiento, que vale la pena tratar de sopesar y de comprender. A este reto respondió la reflexión del profesor Bernhard Waldenfeis con una memorable intervención, publicada primero en francés de modo conciso y resumido, pero recogida luego en su versión definitiva en el capítulo 6 de su libro Topographie des Fremden, volumen primero de los cuatro de que se compone su magna obra Studien zur Phanomenologie des Fremden, publicada por la editorial Suhrkamp de Frankfurt del Meno en 1997. Queremos agradecer al autor y a la editorial su cortesía al permitir que publiquemos la traducción castellana de ese ensayo. "Thinking Europe at its limits", as proposed in 1992 by a group of philosophers from the University of Strasbourg -Denis Guénoun, Philippe Lacoue-Labarthe, Jean-Luc Nancy, Daniel Payot-, means considering what the "geo-philosophy of Europe" is as an essential question that encompasses all truthful reflection surrounding the idea of Europe. The debate, to which a diverse group of colleagues and friends from different nations were invited, advanced the very possibility of an identification of Europe, together with the profoundness, in other words the very violence that this possibility implies, as confirmed time and again since then by recent and highly topical events. The proposal was everything but futile. Indeed, as is well known and was confirmed by the group itself some months later in July 1993, what is certain is that a storm of terrible furores broke out and atrocious upheavals were expressed, both intra- and extra-European, that, if nothing else, urge us to consider whether the project of what deserves to be known as a "world"may or may not be confused with the exclusive exportation of what Europe has invented, produced and identified. The future appears to be in the grip of two morbid figures, two symmetrical nightmares: the myth of a homogeneous planet, like a gigantic Europe spreading everywhere; and a confined Europe, imprisoned in its imprecise and uncertain boundaries, a kind of isolating barricade or trenches enabling it to reclusively consume the illusion of its supposed welfare. This deplorable alternative incites part of our responsibilities, since the arenas of the future necessarily feed off the forms and propositions of thought, which are worthy of an attempt to weigh up and understand. Professor Bernhard Waldenfels responded to this challenge with a memorable intervention, a concise and summarised version of which was first published in French, the final version appearing in Chapter 6 of his book Topographie des Fremden, the first of four volumes that make up his great work Studien zur Phanomenologie des Fremden, published by Suhrkamp of Frankfurt del Meno in 1997. We wish to express our thanks to the author and the publishers for their kind permission to publish the Spanish translation of this essay. (shrink)

O presente artigo parte da ideia de que o conceito conservativo-conservador de sustentabilidade (das florestas, por exemplo) deve ser combinado com a ideia inovadora do ponto de vista tecnológico-económico de desenvolvimento sustentável de modo a formar uma ideia reguladora de desenvolvimento sustentável de acordo com um modelo aberto. O artigo defende que o desenvolvimento tecnológico pode do ponto de vista cultural e institucional ser organizado de uma forma mais sustentável, muito embora a sustentabilidade não tenha ainda sido alcançada tanto do (...) ponto de vista global como do regional Para o autor do artigo, o conceito de desenvolvimento sustentável não é umo ideologia, muito embora a mera consideração anti-capitalista do problema da protecção do ambiente seja passivel de ser considerada ideológica. Segundo o artigo, a protecção da sobrevivencia não deve ser vista em oposição ao desenvolvimento sustentável, antes sim como um ponto de partida para a busca de estratégias e caminhos de sustentabilidade no desenvolvimento. Uma ética do futuro tampouco constitui modelo unilateral relativo às questões de etica ambiental. Segundo o autor, porém, todos os componentes do modelo de desenvolvimento sustentdvel tornados em conjunto resultam numa heuristica de busca pragmáticamente suficiente e adequada para todo e qualquer processo de desenvolvimento sustentável. /// The conservative-conserving concepts of sustainability (offorestry, f. e.) should be combined with the innovative technological-economical idea of sustainable development to a regulative idea of sustainable development according to an open model. Technological development could institutionally-culturally be organised in a more sustainable way, even though sustainability has neither globally nor regionally been reached yet. The concept of sustainability is no ideology, while a simple anticapitalistic view of the conservation problem appears to be ideological itself. Protection of survival is not to be seen as an opposition to sustainable development, but as a starting point of search-strategies for paths of sustainable development. Future-Ethics is also not an explicit search-pattern for questions of ecological ethics. The combined components of the model of sustainable development result in a pragmatically sufficient Search-Heuristics for sustainable development. (shrink)

Las grandes religiones monoteístas –Judaísmo, Cristianismo e Islam– coinciden en anunciar el amor de Dios a los hombres, y reclaman el amor de los hombres a Dios y al prójimo. Sin embargo, una breve mirada a la praxis de estas religiones hace dudar de si este amor no es una mera afirmación, mientras que en la historia y en el presente se impusieron y se imponen las pretensiones exclusivas de verdad mediante el ejercicio de la violencia en contra de los (...) adeptos de la propia religión (“internamente”) y, en especial, en contra de los seguidores de otras religiones (“externamente”) para así alcanzar el poder político. Ahora bien, hay que distinguir entre el justo poder soberano de Dios y la violencia lesiva, además de que el poder soberano de Dios, al igual que el concepto de Dios, no es el mismo en las tres grandes religiones monoteístas. En el Judaísmo domina Dios con amor y como rey; en el Cristianismo, con amor y como servidor; en el Islam, con amor y majestad. Aunque siempre el poder soberano es exclusivo de Dios y nunca se desea la violencia lesiva entre los hombres. Solo así el poder es constitutivo de la naturaleza interna de la religión, mas no de la relación entre las religiones o de las religiones con el mundo: “No hay coacción en la religión”. (shrink)

Johann Georg Hamann, filozof z Królewca, filolog oraz teolog był nazywany przez Goethego „najuczeńszą głową swojego czasu”. Twierdził, że właśnie od niego „najwięcej się nauczył”. Dlatego też zbierał i czytał jego pisma. To samo można powiedzieć o stosunku Ernsta Jüngera do „maga Północy”. Usłyszał o nim przypadkowo w roku 1924 od lipskiego docenta filozofii Hugo Fischera i odtąd był Hamannem zafascynowany. Często powoływał się na niego w węzłowych miejscach twórczości, jak np. w postaci motta z Hamanna w obu wersjach swojej (...) pierwszej pracy Das abenteuerliche Herz. Także dzięki Hamannowi powziął przekonanie, że „wyrazistość jest słusznym podziałem między światłem i cieniem”, jak i to, że najważniejsze fenomeny nie są zjawiskami przyczynowo uszeregowanymi, możliwymi do opanowania przez człowieka, lecz zjawiskami podpowierzchniowo powiązanymi ze sobą. Można je poprzez analogię opisać w zbliżony sposób. Jünger stanął tutaj w jednym szeregu z Hamannem i Goethem. Pod koniec swoich opublikowanych dzienników nazwał swoją znajomość z magiem Północy „nieuniknionym” i zaliczył go do „budzicieli”, którzy uformowali jego charakter. (shrink)

Niniejszy artykuł miał na celu ukazanie zmian zachodzących na przełomie wieków w ocenie wartości utworów literackich. Punktem wyjścia stało się subiektywne odbieranie pojęcia „moralność“. Autor przedstawia kryteria kwalifikujące utwór literacki jak o sztukę lub niesztukę, uwzględniając przy tym obowiązujące w danym okresie reguły prawne, a także związaną z nimi cenzurę. Opierając się n a przykładach, ukazuje, że treść utworu czasami niemoralna czy wręcz pornograficzna nic ma wpływu na wartości literackie i może nawet przysłużyć się sztuce, nauce, celom badawczym czy też (...) pedagogicznym. (shrink)

I love books for many things, but I despise them for introducing a physical limit to the free circulation of knowledge (compared to the Internet). At least, that's what I had always thought. continent. is an online journal aiming at, among other things, breaking with the established paradigms of how academic work has to be published in order to be respected among relevant peers. I'm the engineer behind the current version of continent. , making it work and keeping it running (...) since began in 2010. We provide an online platform for knowledge to circulate, beyond the limitations of institutional attachment or distribution of physical volumes. And regardless of not having a physical publication ourselves, and being a trans-national endeavour with core members spread across three continents, we had the honour to join the Publish Or Be Damned fair and conference of Northern European independent book publishers at Index Art Foundation in Stockholm, Sweden. The place was bursting with exceptional volumes made by some of the most interesting publishers in the European north. The encounter changed the way I think about such books: these editions are designed, engineered and crafted to a level of sophistication that they begin to hold more than just their informational value printed. They convey and communicate a form of tactile knowledge and pleasure, and this completely changed my perspective on the matter. Because continent. had not materialised yet and only appeared in the form of social events (such as those in Basel, Boston, New York, or Zürich), we could not offer any such tactile pleasures to those visiting our booth. Given this, my solution was to turn continent. 's participation into a spectacle of simulation. With so many important figures of the independent publishing world present, we staged a series of imaginary book-launch moments for the camera. Presenting a first quasi-materialisation of continent. in the form of a book, or rather, the hypothetical extrapolation of our red square shape from our logo into a red 30x30 cm slate. Thanks to all those that participated. Your presences allowed continent. to visualise what it would be like if we had a book, and had been published within the honorable circle of these fine publishers. Soon the day will come where this will become reality. Thanks to all who joined the fun and didn't mind me showing these to the rest of the world. I'll publish them here, for them not to perish, even if I shall be damned. Ida Marie Hede Bertelsen ( Pork Salad Press ) Abdul Dube ( sideprojects ) René Sørensen ( sideprojects ) Anders ( OEI Editör ) Brett Bloom ( Half Letter Press ) Anni Puolakkaby ( OK Do ) Kit Hammonds, Kate Phillimore, Louise O'Hare ( Publish and Be Damned ) Ingvar Högni ( Útúrdúr ) Fredrik Ehlin, Andjeas Ejksson, Oscar Mangione ( Geist Magazine ) Klara Källström, Thobias Fäldt ( B-B-B Books ) Laura Hatfield ( Witnas editors ) Chris Johnsen ( WITNAS editors ) Matthew Rana ( Witnas editors ) Ola Ståhl & Carl Lindh ( In Edit Mode Press ) Staffan Lundgren ( Axl Books ) Tuuka Kaila ( NAPA Books ) Vebjørn Guttormsgaard Møllberg + Ingrid Forlang ( Kuk et Parfyme ) Diana Baldon, Joanna Nowotny and Egle Kulbokaite ( Index Foundation ). (shrink)

Certamente, desde que o ser humano existe, a vida nunca esteve isenta de manipulação técnica. Todavia, formas recentes de biotecnologia vão mais longe, tendendo a tornar indiscernível as distinções clássicas entre crescimento natural e produção artificial. Ars sive natura, este poderia ser o novo slogan. Neste sentido, em oposição à bioética corrente que tenta compensar o monismo tecnológico através de um dualismo prático, discutiremos a idéia de que, quando age sobre o Outro (Fremdeneinwirkung), a biotecnologia nunca é puramente técnica, sendo (...) imediatamente prática, ética e política. Por outro lado, confrontada com novos desafios tecnológicos, a fenomenologia necessita assumir certas características de fenomenotecnologia; ações não são nunca meramente práticas. Uma tal combinação entre fenomenologia e fenomenotecnologia abre especiais perspectivas no que diz respeito ao trato da questão da vida humana. Primeiramente, descreveremos o eu corporal como gerador de sua própria história, na medida que evidencia graus de identidade e se constitui como altamente vulnerável. Em segundo lugar, distinguiremos entre a atitude técnica, restrita ao fato de que algo se modifica, e a atitude terapêutica, que se dirige a alguém que sofre: o paciente. A seguir, ultrapassaremos os limites do enquadramento clínico ao considerar novas conquistas no que diz respeito à produção da vida (por exemplo, clonagem e manipulação genética). Antes de simplesmente argumentar pró ou contra, temos de indagar o que significa produzir um eu vivo. Neste contexto, o tempo da poiesis será contrastado com o do pathos. Examinaremos o lugar desde o qual um ser vivo ou pessoal pode ser definido como alguém em si, e pretendemos tencionar simultaneamente o caráter paradoxal de atribuição de um eu ao Outro (Fremdezuschreibung), que assemelha-se ao paradoxo de ter a experiência do Outro como Outro (Fremderfahrung). Pois a pré-história e a pós-história de um alguém específico, incluindo nascimento e morte, é apenas acessível a nós em termos de substituição. Reduzidos a conjuntos de células, seres humanos seriam liberados de tudo isto. Restaria algo sobre o que falamos, mas de modo algum alguém falando a nós. PALAVRAS-CHAVE – Biotecnologia. Terapia. Fenomenologia. Fenomenotecnologia. ABSTRACT Certainly, as long as human beings exist, life has never been exempt from technical manipulations. However, recent forms of biotechnology go further, tending to blur the classical distinction between natural growth and artificial production. Ars sive natura, that may be the new slogan. Now, in opposition to current bioethics which try to compensate the technological monism by means of a practical dualism, we will argue that by acting upon the Other (Fremdeinwirkung) biotechnology is never purely technical, it is immediately practical, ethical and political. On the other side, faced with new technological challenges, phenomenology needs certain features of phenomenotechnology; actions are never merely practical. Such an intertwining of phenomenology and phenomenotechnology opens up special perspectives in dealing with the issue of human life. Firstly, we will describe the bodily self as generating its own history, as showing grades of selfhood and as being highly vulnerable. Secondly, we will distinguish between the technological attitude, restricted on something to be changed, and the therapeutic attitude, addressed to somebody suffering, namely the patient. In the end, we cross the limits of the clinical frame by considering new attempts of life production (e.g. cloning and gene manipulation). Before simply arguing pro and con we have to ask what does it mean to produce a living self. In this context the time of poiesis will be contrasted with the time of pathos. We will examine the place from where a living or personal being may be defined as somebody in itself, and we will simultaneously stress the paradoxical character of ascribing the status of a self to the Other (Fremdzuschreibung), which resembles the paradox of experiencing the Other as an Other (Fremderfahrung). At last, the pre-history and the post-history of a oneself, including birth and death, is only accessible for us by means of substitution. Reduced to cell ensembles, human beings would get rid of all that. There would be left something we speak about, but by no means somebody speaking to us. KEY WORDS – Biotechnology. Therapy. Phenomenology. Phenomenotecnology. (shrink)

Kapitola X., Zánik středověku v které běží o otázku, zda je náš rytíř figurou potvrzující středověk. Don Quijote začíná jako retro-rytíř. Krámuje kusy brnění svých prarodičů. Jeho cíl je, zdá se, inspirován středověce. Ve středověku existovali rytíři, v době Dona Quijote již ne. Přesto se v tomto románu bezúspěšně pátrá po potvrzení věku zvaného „medium aevum“. Je tento věk potvrzen alespoň skrytě? Anebo zjistíme, podíváme-li se na jádro našeho caballero andante, že je jen středověkým převlekem pro opuštění středověku? Následující, zeširoka (...) pojatá „dřevořezba“, dává na tuto otázku jednoznačnou odpověď. (shrink)

This article by Johannes B. Lotz, S.J., never before translated into English, describes his contacts with Martin Heidegger. First it describes his arrival, along with Karl Rahner, S.J., to pursue doctoral studies in Freiburg im Breisgau and their first experiences with the famous professor. Lotz continues his narrative by mentioning times he met with Heidegger over the subsequent forty years up to the philosopher’s death. With Gustav Siewerth, Max Müller, Bernhard Welte, and Karl Rahner, Lotz belonged to a group (...) of Catholic thinkers influenced—some more, some less—by Martin Heidegger. In Lotz’s view some of Heidegger’s ideas were already found in Aquinas, and a philosophy of Being needed to go beyond existential analysis into religion, revelation, and cultural criticism. (shrink)

49th International Congress on Medieval Studies8 May 2014Western Michigan UniversityKalamazoo, Michigan Emmett Randolph Daniel became interested in the subjects of medieval apocalypticism, eschatology and related matters largely on the heels of the pioneering work done in these fields during the 1950s and 1960s by European scholars like Herbert Grundmann,1 Marjorie Reeves,2 Beatrice Hirsch-Reich,3 and Bernhard Töpfer.4 Nearly fifty years later, that is to say, after the publication of his brief but ground-breaking article of 1968 in Speculum on the subject (...) of the Franciscan Joachites,5 one can attest that “Randy” Daniel was for many years an integral part of a new group of distinguished American... (shrink)

Bernhard Deister’s book Anthropologie im Dialog is a comparison of aspects of Karl Rahner’s theology with the psychology of Carl Rogers. Here the dialogue partner of the German philosophical theologian is an American psychologist of influence. The author begins: “These pages present two exemplary pictures of the human person, from theology and psychology. They unfold their approaches in an interdisciplinary dialogue.” The following pages summarize this comparison. Both thinkers see the human being as an active subject living in the (...) tensions between individuality and relation­ship, and then between immanence and transcendence. Building on this, Rogers’ psychology centers on the dynamics and emotions accompanying life with social groups, while Rahner is frequently involved in drawing particular theological disciplines like moral theology or ecclesiology forward into creative reflections on tradi­tion, spirituality, and praxis amid church and society. (shrink)

This article by Johannes B. Lotz, S.J., never before translated into English, describes his contacts with Martin Heidegger. First it describes his arrival, along with Karl Rahner, S.J., to pursue doctoral studies in Freiburg im Breisgau and their first experiences with the famous professor. Lotz continues his narrative by mentioning times he met with Heidegger over the subsequent forty years up to the philosopher’s death. With Gustav Siewerth, Max Müller, Bernhard Welte, and Karl Rahner, Lotz belonged to a group (...) of Catholic thinkers influenced—some more, some less—by Martin Heidegger. In Lotz’s view some of Heidegger’s ideas were already found in Aquinas, and a philosophy of Being needed to go beyond existential analysis into religion, revelation, and cultural criticism. (shrink)

Opposition: Obedience and authority in Exodus 32-34 / George W. Coats -- The theological significance of contradiction within the Book of the Covenant / Paul D. Hanson -- The renewed authority of Old Testament wisdom for contemporary faith / Wayne Sibley Towner -- A stylistic study of the priestly creation story / Bernhard W. Anderson -- "I will not cause it to return" in Amos 1 and 2 / Rolf P. Knierim.

El texto trata del acceso fenomenológico a la muerte. El punto de partida de la reflexión está constituido por la descripción de la muerte que hace Bernhard Welte como un momento en el cual el ser humano alcanza su totalidad. Así, cuando se considera a una persona fallecida, experimentamos una transfiguración en su imagen, de tal modo que el momento de la muerte puede ser calificado como un instante numinoso y sacro. Si se compara esta descripción con el análisis (...) que Martin Heidegger ofrece en Ser y tiempo, constatamos diferentes accesos. Heidegger intenta mostrar que la muerte no puede ser definida por la vía del trato con la muerte de otra persona, sino solo describiendo la relación individual con la propia muerte. Finalmente, el texto discute el concepto que Eugen Fink ofrece de la muerte, el cual tiene dos aspectos: la dimensión solitaria (la propia muerte) y su dimensión social (la muerte de los otros). Ambas dimensiones se complementan. The paper deals with the phenomenological approach to death. The starting point of the reflection is Bernhard Welte’s description of death as a moment in which a human being achieves his wholeness. Thus, when regarding a dead person, we experience a transfiguration in his/her image in such a way that the moment of death can be spoken about as a numinous and sacred instant. Comparing this description with Martin Heidegger’s analysis in Being and Time, we see a different approach. Heidegger attempts to show that death cannot be defined by dealing with the death of another person, but only by describing the individual’s relationship to his/her own death. Finally the text discusses Eugen Fink’s notion of death, which has two aspects: the solitary dimension (one’s own death) and its social dimension (the death of others). Both dimensions are complementary. (shrink)

A Filosofla moderna tem prestado considerável atençao aos enigmas da percepçao sensível. Particularmente tratados tém sido a rela~io entre os objectos materiais percepcionados, os dados sensiveis e a representa~io dos objectos. Menos aten~io tem sido dada á percepçao de entidades imateriais bem como ao sentido mais amplo de 'sentido', ai se incluindo nilo apenas os cinco sentidos exteriores, mas também os sentidos interiores que organizam aquilo que é percebido bem como o sentido último das nossas vidas o qual pode funcionar (...) como um principio organizacional para as actividades da nossa mente. Os teólogos medievais tinham em mente sobretudo este amplo significado da palavra sentido quando se dedicavam á investigaçao da percepçao sensível. Hugo de 5. Victor concentrou-se na percepçao visual do mundo e compreendeu os sentidos internos com base na metáfora do olhar Bernardo de Claraval viu o olhar interno na sua condi~ío de afectado peía queda. Para ele, o ouvido é o primeiro dos sentidos através do qual a verdade pode entrar e gerarfé, a qual por sua vez pode ser usada para ver Deus face-a-face depois da ressurrei~io. A concentraçao moderna na percepçaoo de objectos materiais conduziu a uma subestima~io da percepçao de informa~io imaterial, a qual é vital para a busca de sentido nas nossas vidas, algo que para os autores medievais era considerado óbvio. (shrink)

Wiederkehr des Raumes?. Topologisches Paradigmen ; Rückkehr zum gelebten Raum ; Raumkonzepte und Raumpraktiken ; Regionale oder fundamentale Räumlichkeit ; Zweideutigkeiten und Paradoxien der Lebenswelt -- Polarität von Ort und Raum. Phänomenologische Topik ; Wo-Frage im Schatten der Was-Frage ; Ortsbestimmung als Antwort auf eine Wo-Frage ; Fremde und eigene Wo-Frage ; Hier als Standort : Grund und Boden ; Woher und Wohin : Wegstrecken ; Worin : offene und geschlossene Räume ; Ringsum : Umgebung, Umwelt und Welt ; Wie (...) weit : Vermessene Räume -- Leibliches Wohnen im Raum. Vielfalt des Raumes ; Verankerung im Hier ; Raumachsen ; Durchmessung, Dehnung und Schrumpfung des Raumes ; Nähe und Ferne ; Drinnen und Draußen ; Interieur und Exterieur im Blickfield der Malerei ; Raumanlage und Raumbühne ; Raumtechniken und Ortskarten ; Lokale Räume und globaler Raum -- Ortsverschiebungen. Hier und Anderswo ; Aktualität, Habitualität und Virtualität der räumlichen Bewegung ; Spuren der Zeit im Raum ; Zersprengter Raum ; Telepräsenz ; Fremdorte und andere Räume ; Gemeinorte und globaler Raum ; Gastlichkeit ; Coda : Topos : Atopie : Heterotopien -- Zeitverdoppelung und Zeitverschiebung. Zwischen Mythos und Logos ; Frage nach der Zeit ; Zeitverdoppelung in der Rede und Zeitverkörperung ; Zeitverschiebung zwischen Pathos und Respons ; Zeitverschiebung und Reaktionszeit ; Der entrückte Anfang im Roman und auf der Bühne ; Zeit der Sinne ; Jenseits von Erinnerung und Erwartung ; Rhythmen und Tempi ; Zwischen Leere und Erfüllung ; Coda : Anderswo enden -- Die verändernde Kraft der Wiederholung. Wiederholungsexperiment ; Sich wiederholdende Erfahrung ; Widerholung als Rettung aus der Zeit ; Altes und Neues im Widerstreit ; Unwiederholbares in der Zeit -- Die Wahrscheinlichkeit von Zukünftigem im Anschluß an Aristoteles. Handlungsperspektive ; Die drohende Seeschlacht ; Wahrscheinlichkeit und Häufigkeit ; Zwischen Gewißheit und Ungewißheit ; Rückzug auf pratische Gewißheit ; Zwischen Entwurf und Erwartung ; Unwahrscheinliche Zukunft -- Kommen und Gehen in der Zeit im Anschluß an Merleau-Ponty. Frühe dialektik der Zeit ; Zeit als bloßes Nacheinander ; Totalität der Zeit : Präsenzfeld ; Riß der Zeit : Selbstaffektion ; Bewegung der Zeit : Vor- und Rückläufigkeit ; Wahrnehmung zwischen Vor- und Rückblick ; Handeln zwischen Vorsatz und Vorschlag ; Kommen und Gehen ; Chiasmus der Zeit -- Epilog : Verquickung von Ort, Raum und Zeit. (shrink)

Few would contest the fact that analytical philosophy has dominated philosophical practice in the English speaking world for about the last century. But dispute continues about both its origins and nature; whilst others question its value. Michael Dummett wholly embraced the analytical approach to philosophy, as he conceived of it. For him analytical philosophy marked itself off from its precursors and its alternatives, embodied in the Continental tradition, by taking the linguistic turn. And Frege was unequivocally the first philosopher to (...) take that auspicious turn, which ushered in a new method in philosophy. Henceforth philosophers were to approach the business of analyzing thought via the enterprise of analyzing language. So Dummett is presenting us with both a history lesson and a recommendation about how we ought to do philosophy. But is his reading of the history accurate? And is his conception of the nature of analytical philosophy viable? In order to reflect on these questions this collection brings together eight scholars who have made a serious business of reading Dummett. (shrink)

We discuss two examples of media and public fascination with the interrelated themes of history, identity and heredity, pointing out.

Research carried out during recent decades has revealed our genome not only to be a unique mine of information about health, disease and the human condition, but also about the origin and dispersal history of the species. In this context, the genome is simply an additional source of information about human history, epistemologically no different from other historical sources. However, media and public interpretation of genetic studies of human history are complicated by the wider connotations of genes as the determinants (...) of hereditary features and identity. We discuss two examples of media and public fascination with the interrelated themes of history, identity and heredity, pointing out some implications of historical research using genetic data in the context of our own ongoing study of Inuit groups in Greenland and Victoria Island, Canada. (shrink)

Living corporeity is the intermediate element between nature and culture, which must be thought of as a reciprocal interconnection, since as corporeal beings we always move on a threshold. In the reflection of the bodily self, a doubling between the living body as a functioning subject and as a material object is revealed; after all, even one's own body sometimes takes on the features of a foreign body, as is the case in the experience of illness. In the technical instrument, (...) the body is prolonged and this highlights the connection between the technique of the thing and the technique of the self; however, despite the gradual autonomisation of the technical element from the living corporeity, there remains what escapes calculation and looms large in the subtraction of the alien. (shrink)

An ethical epoché is required to leave the terrain of a self-evident morality and question its origin. In particular, four fundamental motifs of the ethical dimension are identified: pathos, to be thematised as an alternative to the persistent activist unilateralism; response, which always involves body and soul; diastasis with its stumbles and subtractions; and finally coaffection, in which the social dimension of experience is announced. Ethical behaviour feeds on the magma of pathos, which in turn would be blind and directionless (...) without any ethos. (shrink)

Bernhard Nickel presents a theory of generic sentences and the kind-directed modes of thought they express. The theory closely integrates compositional semantics with metaphysics to solve the problem that generics pose: what do generics mean? Generic sentences are extremely simple, yet if there are patterns to be discerned in terms of which are true and which are false, these patterns are subtle and complex. Ravens are black, and lions have manes: statistical measures cannot do justice to the facts, but (...) what else is there that has a hope of giving us insight into what we are capturing across so many domains? Nickel argues that generics are the top of a fundamentally explanatory iceberg, and that this explanatory framework is deeply intertwined with the semantics of the language we use to express them. In providing an integrated semantic and metaphysical theory of generics, he aims to solve old puzzles and draw attention to new phenomena. (shrink)